Welcome to microDTTect.com

Welcome to microDTTect.com - www.microDTTect.com

MicroDTTect is the first completely closed system to collect, transport and process retrieved biomaterials and tissues to diagnose implant- and biofilm-related infections.

MicroDTTect features a special design that allows to store and safely transport any biomaterial or tissue retrieved from a patient and a patented processing antibiofilm compound (dithithreitol, DTT), that allows to dislodge bacteria embedded in biofilms, without affecting their viability and coltural examination.

The closed system provides a completely sterile transportation device, virtually reducing to zero the possibilities of sample contamination.

The DTT antibiofilm compound allows to improve pathogen detection, thus increasing coltural examination sensitivity.

MicroDTTect can be used to collect and process implants and tissues in orthopaedics and trauma, cardio-vascular surgery, neurosurgery, reconstructive and plastic surgery, urology, etc..


Scientific background

MicroDTTect Rationale



 Front Cover 

Periprosthetic Joint Infections: Changing Paradigms. Springer Ed., 2016 



Int J Antimicrob Agents 2017 :

"Fifteen hot topics on joint replacement and prosthetic joint infection (PJI) with controversies and contentious areas were selected and reviewed by members of the Bone and Joint Working Group of the International Society of Chemotherapy (ISC) with co-opted orthopaedic and infection specialist colleagues. A manuscript was prepared following an in-depth review of the current literature, with the aim of providing an insight into these complex issues and, when applicable, to provide personal views from authors’ own experience.

9. [What is the] Role of sonication and/or vortexing or dithiothreitol (DTT) for microbiological diagnosis of prosthetic joint infection and do these have any impact on long-term patient outcome?


"(...) Chemical debonding of bacteria is a novel technique that can provide similar results to sonication and can be applied not only
to retrieved implants but also to other bone and joint tissues.

Treatment of prostheses with dithiothreitol (DTT) may be a reasonable alternative to sonication to improve the detection of biofilm-associated
bacteria in PJI with better sensitivity compared with sonication, especially when the causative micro-organism is Staphylococcus epidermidis. (...)"


J Arthroplasty 2017

 Adv Exp Biol 2016

Injury 2016

Annals Thoracic Surgery 2016

BJJ 2015

J Antimicr Chem 2015

JAC 2014

JOR 2013

Biomed Res Int 2013

CORR 2012

 OrthoAcademy (interview in Italian)


microDTTect is in the Italian Guidelines of the National Society of Microbiology (AMCLI)



amcli2017 amcli2017 [1.092 Kb]

Contacts and links

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